Plavix with omeprazole
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omeprazole (Prilosec). If you're taking one of the drugs listed above Plavix and coffee (not an interaction). Plavix doesn't interact with coffee
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The evidence for the interaction is so overwhelming, the FDA published labeling changes in the prescribing information for Plavix warning against taking it with omeprazole: Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix.
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The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole [Prilosec] or esomeprazole [Nexium]. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix. Plavix Prescribing Information
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Omeprazole can reduce the effectiveness of Plavix, an antiplatelet drug, and increase the risk of cardiovascular events. Learn how omeprazole inhibits the liver enzyme CYP2C19 that transforms Plavix and what alternatives to consider.
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Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix. Avoid using omeprazole concomitantly or 12 hours apart with Plavix. Consider using another acid-reducing agent with less CYP2C19 inhibitory activity Plavix Prescribing Information. If possible, it is recommended to avoid taking Plavix and omeprazole together.
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Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix. Avoid using omeprazole concomitantly or 12 hours apart with Plavix. Consider using another acid-reducing agent with less CYP2C19 inhibitory activity Plavix Prescribing Information. If possible, it is recommended to avoid taking Plavix and omeprazole together.
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The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole [Prilosec] or esomeprazole [Nexium]. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix. Plavix Prescribing Information
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Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (
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prilosec or nexium! While the COGENT trial was negative (no worse CV events with combo plavix/omeprazole vs plavix alone), the study was
Hence Omeprazole being a much more expensive drug than it is now.....